pI: 5.0628 |
Length (AA): 562 |
MW (Da): 59503 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Procyclic. | Siegel TN |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_126788)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G13470 | TCP-1/cpn60 chaperonin family protein |
Arabidopsis thaliana | AT1G55490 | chaperonin 60 subunit beta 1 |
Arabidopsis thaliana | AT3G23990 | heat shock protein 60 |
Arabidopsis thaliana | AT1G26230 | chaperonin 60 subunit beta 4 |
Arabidopsis thaliana | AT2G33210 | heat shock protein 60-2 |
Arabidopsis thaliana | AT3G13860 | heat shock protein 60-3A |
Arabidopsis thaliana | AT5G56500 | chaperonin 60 subunit beta 3 |
Babesia bovis | BBOV_IV006790 | heat shock protein 60, putative |
Brugia malayi | Bm1_56580 | chaperonine protein HSP60 |
Candida albicans | CaO19.717 | similar to S. cerevisiae HSP60 (YLR259C) mitochondrial chaperonin, heat shock protein 60 |
Candida albicans | CaO19.8336 | similar to S. cerevisiae HSP60 (YLR259C) mitochondrial chaperonin, heat shock protein 60 |
Caenorhabditis elegans | CELE_Y22D7AL.5 | Protein HSP-60, isoform A |
Cryptosporidium hominis | Chro.60573 | Hsp60 |
Cryptosporidium parvum | cgd6_4970 | Hsp60; GroEL-like chaperone (ATpase), predicted mitochondrial |
Chlamydia trachomatis | CT_110 | chaperonin GroEL |
Dictyostelium discoideum | DDB_G0288181 | chaperonin 60 |
Drosophila melanogaster | Dmel_CG2830 | Heat shock protein 60 related |
Drosophila melanogaster | Dmel_CG12101 | Heat shock protein 60 |
Drosophila melanogaster | Dmel_CG7235 | CG7235 gene product from transcript CG7235-RA |
Escherichia coli | b4143 | Cpn60 chaperonin GroEL, large subunit of GroESL |
Echinococcus granulosus | EgrG_001190900 | heat shock protein 60 |
Entamoeba histolytica | EHI_178570 | chaperonin 1 60 kDa |
Echinococcus multilocularis | EmuJ_001190900 | heat shock protein 60 |
Giardia lamblia | GL50803_103891 | Chaperonin 60 |
Homo sapiens | ENSG00000144381 | heat shock 60kDa protein 1 (chaperonin) |
Leishmania braziliensis | LbrM.35.2240 | chaperonin HSP60, mitochondrial precursor |
Leishmania braziliensis | LbrM.35.2250 | chaperonin HSP60, mitochondrial precursor |
Leishmania donovani | LdBPK_362140.1 | chaperonin HSP60, mitochondrial precursor |
Leishmania donovani | LdBPK_362130.1 | chaperonin HSP60, mitochondrial precursor |
Leishmania infantum | LinJ.36.2130 | chaperonin HSP60, mitochondrial precursor |
Leishmania infantum | LinJ.36.2140 | chaperonin HSP60, mitochondrial precursor |
Leishmania major | LmjF.36.2020 | chaperonin HSP60, mitochondrial precursor |
Leishmania major | LmjF.36.2030 | chaperonin HSP60, mitochondrial precursor |
Leishmania mexicana | LmxM.36.2020 | chaperonin HSP60, mitochondrial precursor |
Leishmania mexicana | LmxM.36.2030 | chaperonin HSP60, mitochondrial precursor |
Mycobacterium leprae | ML0317 | 65 kDa chaperonin 2 GroEL2 (Protein Cpn60-2) (groEL protein 2) (65 kDa antigen) (Heat shock protein 65) (Cell wall protein A) (A |
Mus musculus | ENSMUSG00000025980 | heat shock protein 1 (chaperonin) |
Mus musculus | 102641967 | 60 kDa heat shock protein, mitochondrial-like |
Mycobacterium tuberculosis | Rv0440 | 60 kDa chaperonin 2 GroEL2 (protein CPN60-2) (GroEL protein 2) (65 kDa antigen) (heat shock protein 65) (cell wall protein A) (a |
Mycobacterium ulcerans | MUL_1393 | chaperonin GroEL |
Neospora caninum | NCLIV_065210 | KLLA0F09449p, related |
Oryza sativa | 4327993 | Os02g0102900 |
Oryza sativa | 4339910 | Os06g0114000 |
Oryza sativa | 4331590 | Os03g0143400 |
Oryza sativa | 4339466 | Os05g0540300 |
Oryza sativa | 4348824 | Os10g0462900 |
Plasmodium berghei | PBANKA_1214000 | heat shock protein 60, putative |
Plasmodium falciparum | PF3D7_1015600 | heat shock protein 60 |
Plasmodium knowlesi | PKNH_0815700 | heat shock protein 60, putative |
Plasmodium vivax | PVX_095000 | heat shock protein 60, putative |
Plasmodium yoelii | PY04614 | heat shock protein 60 |
Saccharomyces cerevisiae | YLR259C | chaperone ATPase HSP60 |
Schistosoma japonicum | Sjp_0215010 | ko:K04077 chaperonin GroEL, putative |
Schistosoma mansoni | Smp_008545 | heat shock protein 60 |
Schmidtea mediterranea | mk4.038932.00 | Hsp60 |
Schmidtea mediterranea | mk4.007026.02 | |
Schmidtea mediterranea | mk4.001987.02 | |
Schmidtea mediterranea | mk4.008170.00 | |
Schmidtea mediterranea | mk4.071758.00 | Chaperonin homolog Hsp-60, mitochondrial |
Schmidtea mediterranea | mk4.034498.00 | Hsp60 |
Schmidtea mediterranea | mk4.007026.01 | |
Schmidtea mediterranea | mk4.008170.01 | |
Trypanosoma brucei gambiense | Tbg972.10.7820 | chaperonin HSP60, mitochondrial precursor, putative |
Trypanosoma brucei gambiense | Tbg972.10.7960 | chaperonin HSP60, mitochondrial precursor |
Trypanosoma brucei | Tb927.10.6510 | chaperonin HSP60, mitochondrial precursor |
Trypanosoma brucei | Tb927.10.6400 | chaperonin HSP60, mitochondrial precursor |
Trypanosoma congolense | TcIL3000.11.15250 | chaperonin HSP60, mitochondrial precursor |
Trypanosoma congolense | TcIL3000_10_5470 | chaperonin HSP60, mitochondrial precursor |
Trypanosoma cruzi | TcCLB.507641.290 | chaperonin HSP60, mitochondrial precursor |
Trypanosoma cruzi | TcCLB.507641.280 | chaperonin HSP60, mitochondrial precursor |
Toxoplasma gondii | TGME49_247550 | heat shock protein HSP60 |
Treponema pallidum | TP0030 | chaperonin GroEL |
Theileria parva | TP04_0066 | heat shock protein 60, putative |
Trichomonas vaginalis | TVAG_203620 | rubisco subunit binding-protein alpha subunit, ruba, putative |
Trichomonas vaginalis | TVAG_167250 | chaperonin, putative |
Trichomonas vaginalis | TVAG_088050 | chaperonin, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0350 | molecular chaperone GroEL |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu443 | Mycobacterium tuberculosis | essential | nmpdr |
Tb927.10.6510 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.6510 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.6510 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.6510 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b4143 | Escherichia coli | essential | goodall |
CELE_Y22D7AL.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_Y22D7AL.5 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_Y22D7AL.5 | Caenorhabditis elegans | slow growth | wormbase |
CELE_Y22D7AL.5 | Caenorhabditis elegans | sterile | wormbase |
YLR259C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1214000 | Plasmodium berghei | Essential | plasmo |
TGME49_247550 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in procyclic forms . | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.